Reply To: Uric Acid Kidney Stone: Will allopurinol help?

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#6037
zip2play
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Quote: Renal clearance of urate is significantly greater during P and A+P treatment compared to baseline and A alone.

Steve,

That’s exactly what I see as the problem here. Any increase in renal clearance will INCREASE your risk of stone formation rather than decrease it. What Allopurinol will do is allow you to produce LESS uric acid to CLEAR! Also, oxypurinol is the first metabolite of allopurinol and a potent xanthine oxidase inhibitor in its own right, more so even than allopurinol itself. Thus increasing its elimination will permit the formation of MORE uric acid from purine rather than less. Allopurinol plus copious amounts of water and urine alkalyzers is the way you want to approach urate kidney stones.

Your ultimate goal is a lifetime of urine with a very low concentration of urate.