Reply To: Febuxostat dose change. Or different time of day?

Stopping Gout Together Forums Help My Gout! The Gout Forum Febuxostat dose change. Or different time of day? Reply To: Febuxostat dose change. Or different time of day?

#8467
d q
Participant


So here are the links and info @nobody and @Keith;

Against Splitting:
1. Contacted Takeda / Menarini directly who have explained that they cannot guarantee uniform active chemical distribution (Febuxostat) throughout the Adenuric tablet at both available doses in the UK. They said they are aware that medical practitioners do occasionally alter/offer doses in this method (for various different reasons) however this is an off-label approach. I asked her to send me the technical document stating this however she said the document is confidential and for internal use only. She will however; send me an email confirming the above.

2. https://www.fda.gov/downloads/aboutfda/centersoffices/officeofmedicalproductsandtobacco/cder/ucm341168.pdf

3. https://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/EnsuringSafeUseofMedicine/ucm184666.htm

In Support of Splitting:
1. https://www.nps.org.au/radar/articles/febuxostat-adenuric-for-chronic-symptomatic-gout – [reading this throws out everything Takeda / Menarini told me however it doesn’t mean to say Takeda are incorrect (distribution of Febuxostat in the Adenuric tablet)].

2. https://www.sciencedirect.com/science/article/pii/S1319016413001254

3. http://www.gout-pal.com/gout-pal-forum/please-help-my-gout/anyone-cut-uloric-80mg-down-to-40mg/ [Interesting post sometime ago here which @Keith mentions a similar situation]

I know I presently need more of the drug but I don’t know how to safely obtain it without going all the way to 120mgs :/

What a pickle this is indeed!