Reply To: Febuxostat and Colchicine dosing

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Hello Sian, being in similar situation I would also like to back a few of nobody’s comments in a concise fashion.

1. Febuxostat is a powerful drug. I took 20mgs and my UA dropped almost 100ummol. Make sure you closely watch the results on UA levels.

2. Check your liver markers (Albumin, Alanine Transaminase, Alkaline Phosphatase, Bilirubin). These are important numbers for Febuxostat as it is metabolised in the liver and not the kidney. These should be checked with every dosage change.

3. Make sure you have a blood test called FBC (Full Blood Count) after starting and increasing dosages of Febuxostat to make sure cell counts are not affected.

4. Ask about a 24hour uric acid excretion test. This should help to get an idea of just how much he’s body is eliminating.

5. Although an MRI will give you a fantastic picture of what is going on try and also get an Ultrasound scan / X-Ray to see if any joint erosion has already taken place.

Take care!