Returning to colchicine dosing, I still struggle to accept that it has any anti-inflammatory effect. So, I never took more than 2 a day (2 times 0.5 g = 1g/day). But, I did rely on ibuprofen – probably because I was used to it, and never had problems (I remember a nurse saying I had a cast iron stomach. She made no comment about any other part of my anatomy). On a few occasions, I supported ibuprofen with intermediate paracetamol (acetaminophen).
That’s when I came up with my 3-pronged strategy of:
– Stop/slow inflammation spreading (colchicine).
– Reduce inflammation (NSAIDs).
– Block residual pain (paracetamol).
Of course, the principles can be applied to different treatment combinations. But, I’m always wary of too much colchicine, based on how it works.