Mood swings before an attack?

Stopping Gout Together Forums Help My Gout! The Gout Forum Mood swings before an attack?

This topic contains 3 replies, has 2 voices, and was last updated by  nobody 5 months, 1 week ago.

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  • #6940

    Steve Bateson
    Ŧallars: Ŧ 4.29
    GoutPal Detective Badge Rank: Detective

    Hello all,

    Really pleased to have found Goutpal and learned a lot from what is here, both the site and the forum.

    First the history

    After 9 years of occaisional and repeated pain that numerous medics could not identify, this time last year I had the mother of all attacks and after much to and fro got a referral to a rheumatologist. One large array of blood tests later and I was given the diagnosis, pretty much along the lines of ‘it’s obviously gout’. Sadly not that obvious to the previous 6 or so medics that were happy to dispense Naproxen and not dig any deeper. Probably my fault for getting it in the achilles, the knees, the ankle in the ball of the foot etc, and not presenting with a throbbing big toe.

    At diagnosis my urate level was 492. Not horrendously high but high enough.
    10 months late after a steadyish drop the last reading was 312. We’re aiming for sub 300, so subject to variation its almost there.

    This has been achieved by (in my rank of effectiveness):-
    Allopurinol 200mg
    Increased hydration
    10kg weight loss
    More exercise, mostly indoor rower
    Vit C supplement 1000mg
    Cherry concentrate capsules.

    I’ve also been using Colchicine. 500ug daily at first, reducing to ‘on demand’ now.

    Obviously I’m not in the clear by a long way, and had to hit the Colchicine again last night but it seems to have worked its magic.

    Now the question.
    I have noticed, retrospectively I must say, that recent attacks have been preceded by a couple of days of unexplained bad moods. Nothing specific, just a general grumpiness and malaise. If I was your puppy you’d be fetching your own stick, that kind of thing. As a result, I find myself wondering about cause and effect.
    Is there something causing the change in mood that is also triggering an attack or is an impending attack from trigger(s) unknown causing the change in mood?

    Does anyone else experience this sensation? I am also wondering if I could use it as an early indicator to take up the Colchicine again.



  • #6941

    Ŧallars: Ŧ 470.84
    GoutPal Scholar Badge Rank: Scholar


    I haven’t noticed such mood swings but see if you can spot other changes happening at the same time like lack of sleep, abnormal sweating, constipation or water loss (very rapid weight loss). I guess one’s diet (and salt in particular) could also trigger both mood swings and attacks.

    It’s not the end of the world if you don’t quite reach 300. If the coldest joints of your body (toes, fingers) never developped uric acid deposits for some reason, a slightly higher value might be fine.

    As more uric acid gets flushed out of your body, the average attack should get progressively shorter.
    Maybe it’s too soon for you to risk it but at some point you might want to try not taking any colchicine when you normally would because the “magic” might not be in the colchicine pill.

  • #6942

    Steve Bateson
    Ŧallars: Ŧ 4.29
    GoutPal Detective Badge Rank: Detective

    Thanks Nobody,

    I’m going to look up salt and mood as it never occurred to me there could be a correlation, however I think you hit the nail when you mentioned tiredness. I believe that is behind the grumpiness.

    I have also just been reading Keith’s article from the current sidebar about gout triggers, and am thinking that the effort of mustering further white cells to tackle dissolving crystals may be draining my resources, so to to speak. That being the case, as I fully subscribe to the ‘lower faster’ mantra, I could be in for a painful 9 months or so based on the one month per year of build-up rule of thumb.

    The 312 reading was just over a month ago and as I’ve stuck with the regime I expect the downward trend will of continued, but guess it will have to level out sometime. Is it normal to be able to reduce the allopurinol dose to a management level in time?


  • #6943

    Ŧallars: Ŧ 470.84
    GoutPal Scholar Badge Rank: Scholar

    I’m not sure what you meant with that last question but the latest guidelines I’ve read do speak of reducing the dose after symptoms have disappeared when the initial target has been set at 300.

    Considering your uric acid has never tested all that high, I very much doubt you’re in for 9 painful months. It may indeed take 9 months or more for your symptoms to go away entierly but, after a few months, your symptoms will hopefully become quite mild.

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