Reply To: Montelukast (Singulair) Asthma Treatment and Gout

Stopping Gout Together Forums Help My Gout! The Gout Forum Montelukast (Singulair) Asthma Treatment and Gout Reply To: Montelukast (Singulair) Asthma Treatment and Gout

#8464
Keith Taylor
Keymaster


There has been another gout-related investigation of Singulair. This time with rats. So still no human trials.

Ibrahim, Mohamed A., Entesar F. Amin, Salwa A. Ibrahim, Walaa Y. Abdelzaher, and Aly M. Abdelrahman. “Montelukast and irbesartan ameliorate metabolic and hepatic disorders in fructose-induced metabolic syndrome in rats.” European journal of pharmacology 724 (2014): 204-210.

Serum levels of uric acid and TNF-α were increased significantly in MetS group compared with normal control. Rats treated with montelukast (10 and 20 mg/kg/day) and irbesartan (30 and 45 mg/kg/day), and a combination of montelukast 5 mg/kg/day plus irbesartan 15 mg/kg/day showed significant decrease in serum levels of uric acid and TNF-α

Any gout sufferers out there with asthma?