Wow, this is very interesting to me 🙂
First, you’ve highlighted one of the mystery areas of high uric acid. Why does high uric acid develop into gout in some people, yet not others? It’s a fascinating topic, though it probably only affects a small number of people. The medics call it unsymptomatic hyperuricemia – i.e. high uric acid with no symptoms.
That’s wrong to me, as they should really say no measurable symptoms. Advances in imaging are now recognizing crystal deposits long before they cause gout. We know that these deposits interfere with natural joint renewal and replacement. Bone, cartilage, and tendons start to suffer, but it takes decades for this to show as joint damage.
And, we have cases like yours where kidney stones form before there is noticeable joint pain. As medical techniques improve, I expect that heart-based tophi, a hidden cause of heart disease, will become more recognized.
In all these cases, simply reducing uric acid with allopurinol is an effective control, though not a cure.
I really wish that you would share your research into allopurinol vs Uloric. If it’s the same research that I’ve read, it infuriates me. Obviously, Takeda’s marketing staff have achieved their goals if you say “many studies find that Uloric is slightly better in helping with Gout.” That’s one of the lies about febuxostat/Uloric that is becoming yet another Gout Myth! It just makes gout treatment harder than it need be. Having said that, we wouldn’t get new gout drugs if pharma companies didn’t line the pockets of their investors, so fair play to them if the licensing authorities are so stupid.
As for toxicity, where has the idea come from that allopurinol is bad for the kidneys? Show me a report that suggests allopurinol hurts your kidneys, and I’ll show you five more that says allopurinol improves kidney health. The real toxicity issue concerns Uloric and the liver, made worse because the FDA put the onus on the patient to check this, rather than the doctor.
In the medical profession, I believe allopurinol is well recognized as a treatment for kidney stones. I’ve seen plenty of research into differential diagnosis for kidney stones. It’s vital to match the right treatment to the right type of stone.
The last sentence worries me –
“most stones are caused by the food you eat, such as cheeses.”
Is this another Internet Health Myth, or is there some believable research?
I’ve always thought that the presence of all kidney stones is due to an imbalance in one or more metabolic systems. Far more complicated than eating cheese. Yet, often easy to treat once the stone composition has been analyzed. Even allopurinol can caused oxypurinol stones if it’s taken with insufficient fluids.
Anyway, please let’s have a proper debate with references back to the research. I’d like to review the page that prompted this discussion, so any contributions are very welcome.