Reply To: Probenecid questions

Keith Taylor

Linda, thanks for the extra info.

Getting that flare after two weeks of changing meds can be one of two things:
1. It would’ve happened anyway.
2. It’s a result of uric acid falling, and more partially dissolved uric acid crystals waking up the immune system.

The only way to know is from your uric acid test results. Increased uric acid takes months to cause a flare. Decreased uric acid might cause one sooner because of the aforementioned partially dissolved crystals. Until your uric acid burden is dissolved, you run a risk of gout flares. There’s very little you can do about that except to go as low as possible to shorten the risk period.