Guidelines for reducing Allopurinol dosage

Stopping Gout Together Forums Help My Gout! The Gout Forum Guidelines for reducing Allopurinol dosage

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    • #9112
      John Fred Doores
      Participant


      Could you repeat the guidelines for reducing Allopurinol dosage after six? Months of around .4 Uric acid readings?

    • #9113
      nobody
      Participant

      Could you clarify your question?
      There is a balance of risks to strike and the details matter a great deal.

      Generally, .4mmol/l is too high for someone who has gout but 4 mg/dl is fine.
      There are guidelines recommending 5 mg/dl or less and guidelines recommending 6mg/dl or less.
      Since it often takes at least a year to get rid of acid uric crystals, the 5mg/dl guidelines seem safer to follow months into the therapy unless there is a specific reason to reduce the dosage (such as bad liver function markers).
      But each case is going to be different. If there are tophi or evidence for other large uric acid deposits, you’d want to keep uric acid as low as possible for instance.

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