Forum Replies Created
March 11, 2021 at 7:32 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10388
My apologies. I missed the dosage of 100mg, as it wasn’t stated in 4 of the 5 of the studies listed. Thank you for pointing that out Keith.March 11, 2021 at 5:52 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10377
And to your earlier response, Allopurinol is not cherry picking. It’s the most widely prescribe drug aimed at lowering uric acid levels in gout sufferers.
There are 9,200,000 gout sufferers in the United States. 0.2% of them is 18,400 people, who would experience Steven Johnson Syndrome or experience severely negative outcomes with the drug. Of those 18,400, approximately 4,600 would die. So, to my original point, try what you can first, before seeking pharmacological remedies, and be cognizant of the risks those pharmaceuticals pose.
“The most commonly used urate-lowering antigout drug, allopurinol, is associated with rare (affecting ~0.2% of patients), but severe, hypersensitivity reactions that are fatal in 25% of cases.105 Pharmacogenetic studies have shown a strong association between HLA-B*5801 and allopurinol-induced Steven–Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) in Korean, Han Chinese, Japanese, Thai106–110 and European populations.111 A meta-analysis based on these studies showed that patients who expressed the HLA-B*5801 allele had an 80–97-fold increased risk of developing SJS or TEN in response to allopurinol compared with patients who did not express the allele.112”
Finally, no one is cherry picking, other than you, who dismisses peer reviewed research out of hand over your own personal bias. You’re welcome to your opinion, as I had given in my initial post on this thread, and you’re welcome to disagree w/others opinions by substantiating your disagreements, however you have yet to actually substantiate anything from what I can tell in this conversation, and have instead mischaracterized my statements multiple times. For instance, drugs like colchicine means drugs intended to treat inflammation, not NSAIDS, but you brought up NSAIDS because its an easy straw man to dismiss my claims out of hand, once again.
It’s likely that you know more about your own condition than most doctors do, as most doctors have a general set of rules/guidelines to follow that mainly operate on trial/error, due to the genetic variability in patients. There are over a dozen different genes that code for gout, and the combination of them impact what treatments will work, and which wont. They also impact how you respond to each of the different medications available.
Gout is a condition that needs a considerable amount of additional research, and having humility when discussing said condition is desperately needed.March 11, 2021 at 5:30 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10376
Well look at that Nobody, it seems you agree with the “garbage” study I posted…
“If I may repeat myself, the reason most people who come here shouldn’t care is that most people aren’t going to be able to treat their gout through diet anyway.”
The study posits that diet has little to do with the variation of serum uric acid levels, and that genetic factors play a much bigger role.March 10, 2021 at 6:10 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10358
I’m not confusing anything with anything, but hey, what do I expect arguing with a troll named Nobody.
Have a good day.March 10, 2021 at 5:45 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10356
That depends entirely upon the age of the patient, and the drug in question. Popular drugs like Allopurinol have a lot of long term health risks, and are associated with an increase in mortality.
Febuxostat has been known to increase the rate of heart attack in patients.
Drugs like Colchicine are fairly low risk, but may not be entirely effective, depending on how your body metabolizes/interacts with them.
With all drugs, especially some of the gout drugs, there runs the risk of interactions when treating acute health issues. The more drugs you take, the more likely you are going to find an interaction. Overall, the fewer pharmaceuticals you have in your system, the less you have to worry about potential interactions. Example: If you are taking DayQuil or something with dexomethorphan to treat a cold, and end up taking sumatriptan at the same time for a migraine, you could find that you go to sleep and never wake up again, as both operate on the seratonin system. If you are on a long term prescription of say, Allopurinol, you now have a smaller tool box to treat acute health problems and run the risk of interactions you aren’t expecting.
Point is, drugs aren’t always the best option, especially if you can find a non-medicinal way of preventing flairs. I’m 33. Taking a drug for the rest of my life runs the risk of cumulative harm, as there is no biological free lunch. For someone who is young, if a solution that is non-pharmaceutical can be found, it’s likely to have less of a negative impact down the road. So, once again, genetics and other factors play a big role in how to address gout, and one should be encouraged to try as many different solutions, in a scientific manner, as possible before resorting to pharmaceutical interventions.
To address your other comments: No one in this forum has suggested treating a gout attack with a dietary change. Dietary guidelines are prophylactic/preventative. So, why you are bringing that up is beyond me. Everything I’ve discussed thus far has been about preventing further attacks.
Furthermore, if one is claiming that diet impacts your uric acid levels and thus, hyperuricemia, then one is postulating that dietary factors are “triggers” of gout attacks, as the consumption of said foods would lead to hyperuricemia and then a gout attack. So, again, your response makes little sense in this conversation.March 10, 2021 at 5:05 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10354
There’s no intentional misguiding here. Your comments are intentionally derisive and assume you know better than everyone else. Mine are providing an alternate perspective on the disease, as I have been suffering with it for over a decade and understand it well.
None of the recommendations on dietary restrictions worked for me. The only thing that has ever helped is water consumption. This is indicative of genetic factors playing a larger role in gout flares than dietary guidelines that assume everyones triggers are the same.
Point is, if the dietary guidelines aren’t helping, try something else like increasing water and see if that helps. Maybe it will, maybe it wont. Everyone is different. Assuming otherwise is arrogance.March 10, 2021 at 4:47 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10351
I’m sorry. I didn’t know this was one of those forums where we are rude to each other.
I’ve followed the dietary guidelines, it never helped. The only thing that’s ever helped is water consumption. Considering I spent an entire year drinking bourbon/beer daily, red meat, and all the things I wasn’t supposed to, and had ZERO gout flares because I simply drank more water, anecdotally, goes to show what “garbage” those dietary recommendations are.
But hey, go ahead and continue to advise something that doesn’t work. I’ll let you be rude to other people ✌️March 10, 2021 at 3:47 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10348
Another thing to mention is that the Gout Diet recommendations are likely not going to have much of an impact on your actual gout flares. Recent studies are showing that diet doesn’t really have a noticeable impact on your uric acid levels, and that it is almost solely genetic factors that drive gout flares. For instance, the study below shows that dietary factors have a less than 0.3% variance in uric acid levels, to whereas genetic factors vary those levels by as much as 23%.
So, drink more water to help your body process and flush it from your system, and don’t worry too much about your diet.
Seven foods were associated with raised serum urate levels (beer, liquor, wine, potato, poultry, soft drinks, and meat (beef, pork, or lamb)) and eight foods were associated with reduced serum urate levels (eggs, peanuts, cold cereal, skim milk, cheese, brown bread, margarine, and non-citrus fruits) in the male, female, or full cohorts. Three diet scores, constructed on the basis of healthy diet guidelines, were inversely associated with serum urate levels and a fourth, data driven diet pattern positively associated with raised serum urate levels, but each explained ≤0.3% of variance in serum urate. In comparison, 23.9% of variance in serum urate levels was explained by common, genome wide single nucleotide variation.
In contrast with genetic contributions, diet explains very little variation in serum urate levels in the general population.”March 10, 2021 at 2:50 pm in reply to: Stopped drinking beer, good gout diet, but foot swollen #10347
I’ve had gout since my early 20’s. Loved beer, still love bourbon. Here’s a simple bit of advice that keeps you away from the doctor.
Drink 1/2 to a full gallon of water every day. When I adhere to that 1 thing, I can pretty much enjoy whatever I want without risk of a gout attack. The days I don’t, I will feel the gout moving in.
Example, I haven’t had alcohol in 10 days, but have had some bbq brisket. I drank only 1/4 gallon of water yesterday w/2 cups of coffee and woke up today with gout in my ankle. It’s not just about what you eat, it’s about ensuring your body has the proper hydration.
Suck down the water, and you should see the frequency of your attacks reduced. When one does begin to surface, hit the indomethacin quick, before it turns into a full blown attack.
Just my $0.02, good luck!